
Association for Long Term Existence and Resilience (ALTER)
ALTER (Association for Long Term Existence and Resilience) is an Israeli nonprofit that investigates, demonstrates, and fosters practical approaches to safeguard humanity's long-term future. Founded by David Manheim in 2021, the organization works across three pillars: research on AI safety and biosecurity, policy engagement with decision-makers on risk-resilient regulation both domestically and globally, and community building among researchers and practitioners focused on catastrophic risk reduction. ALTER is a member of the NIST AI Safety Consortium, participates in ISO standards development for AI oversight, and engages with the WHO-hosted International Pathogen Surveillance Network.
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Theory of Change
ALTER believes that existential and catastrophic risks, particularly from advanced AI and engineered pandemics, can be mitigated through a combination of rigorous academic research, evidence-based policy advocacy, and building a community of practitioners focused on long-term thinking. By producing research that identifies concrete failure modes and risk factors, engaging directly with standards bodies like NIST and ISO to shape AI oversight frameworks, and building relationships with policymakers in Israel and internationally, ALTER aims to ensure that governance structures keep pace with emerging technologies. Their work on AI safety standards, biosecurity regulation, and international cooperation frameworks is intended to create institutional infrastructure that reduces the probability and severity of catastrophic outcomes.
Grants Received
from Open Philanthropy
from Survival and Flourishing Fund
from Survival and Flourishing Fund
from Survival and Flourishing Fund
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Details
- Last Updated
- Apr 2, 2026, 10:09 PM UTC
- Created
- Mar 18, 2026, 11:18 PM UTC